3-D Chromatin  Remodeling &


'single molecule to whole genome'


Davó-Martínez C, Helfricht A, Ribeiro-Silva C, Raams A, Tresini M, Uruci S, van Cappellen WA, Taneja N, Demmers JAA, Pines A, Theil AF, Vermeulen W, Lans W. Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination. (Nucleic Acid Research 2023, DOI: 10.1093/nar/gkad609)

Gaggioli V, Lo CSY, Reverón-Gómez N, Jasencakova Z, Domenech H, Nguyen H,  Sidoli S, Tvardovskiy A, Uruci S, Slotman JA, Chai Y, Goncalves JG, Manolika EM, Jensen ON, Wheeler D, Sridharan S, Chakraborty S, Demmers J, Kanaar R, Groth A, Taneja N*. Dynamic de novo heterochromatin assembly and disassembly at replication forks ensure fork stability. (Nature Cell Biology 2023, DOI: 10.1038/s41556-023-01167-z)

          This article was selected for News & Views in Nature Cell Biology by Susan M. Gasser. Transient chromatin compaction in fork restart. (Nature Cell Biology 2023, DOI: 10.1038/s41556-023-01181-1)


Chakrabarty S, Quiros-Solano, Kuijten M, Haspels B, Mallya S, Lo CSY, Othman A, Gaio N, Odijk H, van de Ven, de Ridder, Weerden W, Jonkers J, Dekker R, Taneja N, Kanaar R, van Gent D. A microfluidic cancer-on-chip platform predicts drug response using organotypic tumor slice culture. (Cancer Research 2022, PMID: 34872965)

Chakraborty S; Singh M; Pandita R; Singh V; Lo CSY; Leonard F; Horikoshi N; Hunt C; Makhijani K; Chau E; Godin B; Scherthan H; Deck J; Hausmann M; Bhat K; Taneja N; Das C; Pandita T. Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks. (iScience 2022, PMID: 35434547)

Uruci S, Lo CSY, Wheeler D, Taneja N*. R-Loops and Its Chro-Mates: The Strange Case of Dr. Jekyll and Mr. Hyde. (IJMS 2021, PMID: 34445553)

DiPiazza ARC, Taneja N, Dhakshnamoorthy J, Wheeler D, Holla S, Grewal SIS. Spreading and epigenetic inheritance of heterochromatin requires a critical density of histone H3 lysine 9 tri-methylation. (PNAS, 2021; PMID:34035174)


Lo CSY, van Toorn M, Gaggioli V, Dias MP, Zhu Y, Manolika EM, Zhao W, van der Does M, Goncalves JG, van Royen M, French P, Demmers J, Smal I, Lans H, Wheeler D, Jonkers J, Ray Chaudhuri A, Marteijn JA, Taneja N*. SMARCAD1 Mediated Active Replication Fork Stability Maintains Genome Integrity. (Science Advances 2021, PMID: 33952518)

Taneja N* and Grewal SI. Shushing Histone Turnover: It's Fun Protecting Epigenome-Genome. (Cell Cycle 2017, PMID: 28805495)

Taneja N, Zofall M, Balachandran V, Thillainadesan G, Sugiyama T, Wheeler D, Zhou M, Grewal SI. SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication. (Molecular Cell 2017, PMID:28318821)

        This article was selected for Preview in Molecular Cell. Fortuny A and Polo SE. Genome and Epigenome Maintenance by Keeping Histone Turnover in Check. (Molecular Cell 2017, DOI: 10.1016/j.molcel.2017.03.015)

Mizuguchi T, Taneja N, Fudenberg G, Belton JM, FitzGerald P, Mirny LA, Dekker J, Grewal SI. Sheltrin Components Mediates Genome Reorganization in Response to Replication Stress. (PNAS 2017, PMID: 28490498)


Mizuguchi T, Fudenberg G, Mehta S, Belton JM, Taneja N, Folco HD, FitzGerald P, Dekker J, Mirny L, Barrowman J, Grewal SI. Cohesin-Dependent Globules and Heterochromatin Shape 3D Genome Architecture in S. pombe. (Nature 2014, PMID: 25307058)


Lee NN, Chalamcharla VR, Reyes-Turcu F, Mehta S, Zofall M,  Balachandran  V, Dhakshnamoorthy J, Taneja N, Yamanaka S, Zhou M, Grewal SI. Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance. (Cell 2013, PMID: 24210919)


Raychaudhuri N*, Dubruille R, Orsi GA, Bagheri HC, Loppin B, Lehner CF. Transgenerational Propagation and Quantitative Maintenance of Paternal Centromeres Depends on Cid/Cenp-A Presence in Drosophila Sperm. (Plos Biology 2012, PMID:23300376)

* Raychaudhuri N. mentioned here is Taneja N.


     This article was selected for News & Views in Epigenomics. Shiota H, Goudarzi A, Rousseaux S, Khochbin S. Transgenerational inheritance of chromatin states. (Epigenomics 2013, 10.2217/epi.13.12)


INTERNATIONAL PATENT #PCT/NL2023/050120. Nascent Chromatin Fibre Isolation in a controlled laminar flow environment

Lead Inventor: Taneja N*; Co-inventors: Gaggioli V, Kanaar R



Copyright 2023 @Taneja lab